' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 4 Researches
7.5
USERS' SCORE
Very Good
Based on 21 Reviews
8.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
667 mcg DFE (400 mcg Folic Acid)
167%
Calcium (as Calcium Carbonate)
100 mg
8%
Top Medical Research Studies
8
Folate's potential in heart health
Atherogenic Effect of Homocysteine, a Biomarker of Inflammation and Its Treatment.
Relevant to cardiovascular health
We have explored how folate, a vital B-vitamin, may play a crucial role in lowering homocysteine levels, which is linked to heightened risks of cardiovascular diseases. The study highlights how high levels of homocysteine can contribute to atherosclerosis, a silent but dangerous condition leading to heart disease and stroke.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
Read More
7
Folate may slow atherosclerosis progression
Serum folate levels, but not vitamin B12, are associated with slower progression in carotid intima-media thickness in a population exposed to mandatory folic acid fortification.
Relevant but limited findings
We explored the relationship between folate and vitamin B12 levels and their impact on cardiovascular health by studying participants from São Paulo, Brazil. Specifically, we aimed to understand how these vitamins relate to changes in carotid intima-media thickness (cIMT), a key marker for early atherosclerosis.
Over a median follow-up of eight years, we observed that the majority of participants had adequate levels of these vitamins, thanks in part to mandatory folic acid fortification in food. Our findings indicated that individuals with the highest serum folate levels experienced a slower increase in cIMT compared to those with the lowest levels. In particular, the fourth quartile of serum folate showed a significant association with reduced cIMT progression.
Interestingly, we found no such effect with vitamin B12. Additionally, dietary folate intake was not linked to changes in cIMT. This suggests that while folate might play a beneficial role in cardiovascular health, vitamin B12 does not appear to have the same effect in this population.
Overall, our study highlights the potential importance of maintaining adequate folate levels for cardiovascular health, especially in regions with fortified food. However, it's essential to note that there were no significant deficiencies in these vitamins in our cohort, which underscores the effectiveness of food fortification programs.
Over a median follow-up of eight years, we observed that the majority of participants had adequate levels of these vitamins, thanks in part to mandatory folic acid fortification in food. Our findings indicated that individuals with the highest serum folate levels experienced a slower increase in cIMT compared to those with the lowest levels. In particular, the fourth quartile of serum folate showed a significant association with reduced cIMT progression.
Interestingly, we found no such effect with vitamin B12. Additionally, dietary folate intake was not linked to changes in cIMT. This suggests that while folate might play a beneficial role in cardiovascular health, vitamin B12 does not appear to have the same effect in this population.
Overall, our study highlights the potential importance of maintaining adequate folate levels for cardiovascular health, especially in regions with fortified food. However, it's essential to note that there were no significant deficiencies in these vitamins in our cohort, which underscores the effectiveness of food fortification programs.
Read More
8
Folate lowers stroke risk
Association Between Serum Folate Concentrations and 10-Year Stroke Risk in a Prospective Community Cohort: Mediation and Interaction Analyses.
Moderate relevance to cardiovascular disease.
We explored the connection between serum folate levels and stroke risk by examining a diverse group of 4,903 individuals from a Chinese community. Over a follow-up period of about 9.3 years, we recorded a total of 407 strokes, with the majority being ischemic strokes.
Our analysis revealed that individuals with higher folate levels (specifically those in the highest quartile, at 8.2 ng/mL or more) had a significantly lower risk of stroke. The data showed a hazard ratio of 0.68, indicating that these individuals were less likely to experience a stroke compared to those with lower folate levels.
An intriguing find was that homocysteine (Hcy) acted as a mediator in this relationship, accounting for about 14.5% of the connection between folate and stroke risk. Furthermore, we discovered that genetic factors, specifically the MTHFR gene polymorphism, could influence this relationship. We found that having the C677T genotype correlated with a positive impact of folate on stroke risk, while no such correlation was apparent for individuals with the other genotype.
Overall, the study suggests that adequate folate levels may be vital for reducing long-term stroke risk, with certain genetic variations playing a role in how folate affects cardiovascular health.
Our analysis revealed that individuals with higher folate levels (specifically those in the highest quartile, at 8.2 ng/mL or more) had a significantly lower risk of stroke. The data showed a hazard ratio of 0.68, indicating that these individuals were less likely to experience a stroke compared to those with lower folate levels.
An intriguing find was that homocysteine (Hcy) acted as a mediator in this relationship, accounting for about 14.5% of the connection between folate and stroke risk. Furthermore, we discovered that genetic factors, specifically the MTHFR gene polymorphism, could influence this relationship. We found that having the C677T genotype correlated with a positive impact of folate on stroke risk, while no such correlation was apparent for individuals with the other genotype.
Overall, the study suggests that adequate folate levels may be vital for reducing long-term stroke risk, with certain genetic variations playing a role in how folate affects cardiovascular health.
Read More
Most Useful Reviews
9.5
Improved hemoglobin levels
Folic acid aids in treating anaemia. I take it alongside iron supplements to improve my haemoglobin levels. Folic acid enhances iron absorption. It’s often mistakenly viewed as solely for pregnant women, but deficiency can occur in anyone, especially those with gastrointestinal issues. I've raised my haemoglobin to target levels without side effects.
Read More
9.5
No discomfort experienced
This supplement aids in red blood cell production and maintains cardiovascular health. I have not experienced any discomfort after taking it, and it's affordable; I will buy it again.
Read More
9.5
Supports overall health
21st Century Folic Acid is excellent for overall health, particularly for women. The easy-to-swallow tablets are made with high-quality ingredients, promoting cardiovascular health and cell production. I highly recommend it for daily intake.
Read More
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Most Likely Effective
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7.5
8
Folate lowers stroke risk
Association Between Serum Folate Concentrations and 10-Year Stroke Risk in a Prospective Community Cohort: Mediation and Interaction Analyses.
Moderate relevance to cardiovascular disease.
We explored the connection between serum folate levels and stroke risk by examining a diverse group of 4,903 individuals from a Chinese community. Over a follow-up period of about 9.3 years, we recorded a total of 407 strokes, with the majority being ischemic strokes.
Our analysis revealed that individuals with higher folate levels (specifically those in the highest quartile, at 8.2 ng/mL or more) had a significantly lower risk of stroke. The data showed a hazard ratio of 0.68, indicating that these individuals were less likely to experience a stroke compared to those with lower folate levels.
An intriguing find was that homocysteine (Hcy) acted as a mediator in this relationship, accounting for about 14.5% of the connection between folate and stroke risk. Furthermore, we discovered that genetic factors, specifically the MTHFR gene polymorphism, could influence this relationship. We found that having the C677T genotype correlated with a positive impact of folate on stroke risk, while no such correlation was apparent for individuals with the other genotype.
Overall, the study suggests that adequate folate levels may be vital for reducing long-term stroke risk, with certain genetic variations playing a role in how folate affects cardiovascular health.
Our analysis revealed that individuals with higher folate levels (specifically those in the highest quartile, at 8.2 ng/mL or more) had a significantly lower risk of stroke. The data showed a hazard ratio of 0.68, indicating that these individuals were less likely to experience a stroke compared to those with lower folate levels.
An intriguing find was that homocysteine (Hcy) acted as a mediator in this relationship, accounting for about 14.5% of the connection between folate and stroke risk. Furthermore, we discovered that genetic factors, specifically the MTHFR gene polymorphism, could influence this relationship. We found that having the C677T genotype correlated with a positive impact of folate on stroke risk, while no such correlation was apparent for individuals with the other genotype.
Overall, the study suggests that adequate folate levels may be vital for reducing long-term stroke risk, with certain genetic variations playing a role in how folate affects cardiovascular health.
Read More
8
Folate's potential in heart health
Atherogenic Effect of Homocysteine, a Biomarker of Inflammation and Its Treatment.
Relevant to cardiovascular health
We have explored how folate, a vital B-vitamin, may play a crucial role in lowering homocysteine levels, which is linked to heightened risks of cardiovascular diseases. The study highlights how high levels of homocysteine can contribute to atherosclerosis, a silent but dangerous condition leading to heart disease and stroke.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
Read More
7
Folate may slow atherosclerosis progression
Serum folate levels, but not vitamin B12, are associated with slower progression in carotid intima-media thickness in a population exposed to mandatory folic acid fortification.
Relevant but limited findings
We explored the relationship between folate and vitamin B12 levels and their impact on cardiovascular health by studying participants from São Paulo, Brazil. Specifically, we aimed to understand how these vitamins relate to changes in carotid intima-media thickness (cIMT), a key marker for early atherosclerosis.
Over a median follow-up of eight years, we observed that the majority of participants had adequate levels of these vitamins, thanks in part to mandatory folic acid fortification in food. Our findings indicated that individuals with the highest serum folate levels experienced a slower increase in cIMT compared to those with the lowest levels. In particular, the fourth quartile of serum folate showed a significant association with reduced cIMT progression.
Interestingly, we found no such effect with vitamin B12. Additionally, dietary folate intake was not linked to changes in cIMT. This suggests that while folate might play a beneficial role in cardiovascular health, vitamin B12 does not appear to have the same effect in this population.
Overall, our study highlights the potential importance of maintaining adequate folate levels for cardiovascular health, especially in regions with fortified food. However, it's essential to note that there were no significant deficiencies in these vitamins in our cohort, which underscores the effectiveness of food fortification programs.
Over a median follow-up of eight years, we observed that the majority of participants had adequate levels of these vitamins, thanks in part to mandatory folic acid fortification in food. Our findings indicated that individuals with the highest serum folate levels experienced a slower increase in cIMT compared to those with the lowest levels. In particular, the fourth quartile of serum folate showed a significant association with reduced cIMT progression.
Interestingly, we found no such effect with vitamin B12. Additionally, dietary folate intake was not linked to changes in cIMT. This suggests that while folate might play a beneficial role in cardiovascular health, vitamin B12 does not appear to have the same effect in this population.
Overall, our study highlights the potential importance of maintaining adequate folate levels for cardiovascular health, especially in regions with fortified food. However, it's essential to note that there were no significant deficiencies in these vitamins in our cohort, which underscores the effectiveness of food fortification programs.
Read More
7
Folate's role in hypertension examined
Hypertension and global DNA methylation: a population-based study in rural, Punjab, India.
Highlights folate and hypertension link
We explored the relationship between hypertension and global DNA methylation levels in a group of 2,300 individuals aged 30 to 75 from rural Punjab, India. Our research particularly aimed to see how folate, along with other vitamins and biochemical markers, affects blood pressure and cardiovascular health.
After screening, we identified 900 individuals—450 with hypertension and 450 without. The results revealed that those suffering from hypertension had significantly lower levels of global DNA methylation compared to those who were normotensive. Intriguingly, individuals with the lowest levels of DNA methylation were at a notably increased risk for hypertension.
Another key finding was that hypertensive individuals who were on medication and had controlled blood pressure showed higher levels of DNA methylation than those with uncontrolled hypertension. This suggests that managing blood pressure effectively, combined with adequate folate levels, might help improve methylation, a crucial process linked to health.
Overall, this study highlights the complex interconnections between folate, global DNA methylation, and hypertension, suggesting that folate could play an important role in managing cardiovascular health in our rural population.
After screening, we identified 900 individuals—450 with hypertension and 450 without. The results revealed that those suffering from hypertension had significantly lower levels of global DNA methylation compared to those who were normotensive. Intriguingly, individuals with the lowest levels of DNA methylation were at a notably increased risk for hypertension.
Another key finding was that hypertensive individuals who were on medication and had controlled blood pressure showed higher levels of DNA methylation than those with uncontrolled hypertension. This suggests that managing blood pressure effectively, combined with adequate folate levels, might help improve methylation, a crucial process linked to health.
Overall, this study highlights the complex interconnections between folate, global DNA methylation, and hypertension, suggesting that folate could play an important role in managing cardiovascular health in our rural population.
Read More
User Reviews
USERS' SCORE
Very Good
Based on 21 Reviews
8.7
9.5
Improved hemoglobin levels
Folic acid aids in treating anaemia. I take it alongside iron supplements to improve my haemoglobin levels. Folic acid enhances iron absorption. It’s often mistakenly viewed as solely for pregnant women, but deficiency can occur in anyone, especially those with gastrointestinal issues. I've raised my haemoglobin to target levels without side effects.
Read More
9.5
Supports heart health
Folic acid, a crucial B vitamin, supports heart health. Regular intake may reduce stroke risk and cardiovascular disorders, normalising blood pressure and cholesterol levels. It's particularly important during pregnancy for fetal development and preventing early birth.
9.5
Prevents anaemia
Folic acid is crucial when planning a pregnancy and overall health. Its deficiency can result in anaemia and gastrointestinal issues. It helps control homocysteine, a harmful substance linked to cardiovascular disease and facilitates proper metabolic functions.
9.5
No discomfort experienced
This supplement aids in red blood cell production and maintains cardiovascular health. I have not experienced any discomfort after taking it, and it's affordable; I will buy it again.
9.5
Supports overall health
21st Century Folic Acid is excellent for overall health, particularly for women. The easy-to-swallow tablets are made with high-quality ingredients, promoting cardiovascular health and cell production. I highly recommend it for daily intake.
