Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.4
USERS' SCORE
Good
Based on 21 Reviews
8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
667 mcg DFE (400 mcg Folic Acid)
167%
Calcium (as Calcium Carbonate)
100 mg
8%
Top Medical Research Studies
8
We examined the connection between folic acid levels and stroke risk in a study involving nearly 5,000 individuals from a Chinese community. We discovered that participants with higher folate levels had a significantly lower risk of experiencing strokes.
Specifically, those in the highest folate group had a 32% lower risk of stroke compared to those with the lowest levels. We also found that homocysteine levels played a significant role in this relationship. Interestingly, the genetic variation of the MTHFR gene influenced how folate affected stroke risk, revealing a more complex interaction.
Specifically, those in the highest folate group had a 32% lower risk of stroke compared to those with the lowest levels. We also found that homocysteine levels played a significant role in this relationship. Interestingly, the genetic variation of the MTHFR gene influenced how folate affected stroke risk, revealing a more complex interaction.
Read More
8
Folate impacts heart health progression
We focused on whether folate and vitamin B12 levels influence the progression of carotid intima-media thickness (cIMT), an early sign of atherosclerosis. Our research covered over 4,200 participants in São Paulo over eight years.
While vitamin B12 showed no significant connection, participants with the highest folate levels experienced a slower increase in cIMT compared to those with the lowest levels. This highlights folate’s potential positive impact on cardiovascular health, particularly in populations with adequate serum folate.
While vitamin B12 showed no significant connection, participants with the highest folate levels experienced a slower increase in cIMT compared to those with the lowest levels. This highlights folate’s potential positive impact on cardiovascular health, particularly in populations with adequate serum folate.
Read More
8
We explored the role of the MTHFR C677T gene polymorphism in patients with coronary heart disease and hypertension using folic acid along with enalapril treatment. Over 540 patients were divided into groups based on folic acid treatment and monitored for a year.
We observed that those receiving folic acid had a lower recurrence of cardiovascular events compared to others. Additionally, the lipid levels showed improvement in the folic acid group. Therefore, folic acid may enhance overall treatment outcomes and patient compliance in managing blood pressure.
We observed that those receiving folic acid had a lower recurrence of cardiovascular events compared to others. Additionally, the lipid levels showed improvement in the folic acid group. Therefore, folic acid may enhance overall treatment outcomes and patient compliance in managing blood pressure.
Read More
Most Useful Reviews
9
Improved hemoglobin levels
5 people found this helpful
Folic acid aids in treating anaemia. I take it alongside iron supplements to improve my haemoglobin levels. Folic acid enhances iron absorption. It’s often mistakenly viewed as solely for pregnant women, but deficiency can occur in anyone, especially those with gastrointestinal issues. I've raised my haemoglobin to target levels without side effects.
Read More
9
No discomfort experienced
This supplement aids in red blood cell production and maintains cardiovascular health. I have not experienced any discomfort after taking it, and it's affordable; I will buy it again.
Read More
9
Supports overall health
21st Century Folic Acid is excellent for overall health, particularly for women. The easy-to-swallow tablets are made with high-quality ingredients, promoting cardiovascular health and cell production. I highly recommend it for daily intake.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.4
- All Researches
We investigated the link between maternal folic acid supplementation and the risk of congenital heart disease (CHD) in children, considering genetic factors too. In a hospital-based case-control study with 595 children diagnosed with CHD and 605 healthy children, we found that mothers who took folic acid reduced the risk of CHD in their children.
The data indicated a noteworthy interaction between maternal supplementation and certain genetic variants in the children, particularly one MTRR gene polymorphism. However, it's important to note that further research with larger samples is necessary to strengthen these findings.
The data indicated a noteworthy interaction between maternal supplementation and certain genetic variants in the children, particularly one MTRR gene polymorphism. However, it's important to note that further research with larger samples is necessary to strengthen these findings.
Read More
8
We examined the connection between folic acid levels and stroke risk in a study involving nearly 5,000 individuals from a Chinese community. We discovered that participants with higher folate levels had a significantly lower risk of experiencing strokes.
Specifically, those in the highest folate group had a 32% lower risk of stroke compared to those with the lowest levels. We also found that homocysteine levels played a significant role in this relationship. Interestingly, the genetic variation of the MTHFR gene influenced how folate affected stroke risk, revealing a more complex interaction.
Specifically, those in the highest folate group had a 32% lower risk of stroke compared to those with the lowest levels. We also found that homocysteine levels played a significant role in this relationship. Interestingly, the genetic variation of the MTHFR gene influenced how folate affected stroke risk, revealing a more complex interaction.
Read More
8
Folate impacts heart health progression
We focused on whether folate and vitamin B12 levels influence the progression of carotid intima-media thickness (cIMT), an early sign of atherosclerosis. Our research covered over 4,200 participants in São Paulo over eight years.
While vitamin B12 showed no significant connection, participants with the highest folate levels experienced a slower increase in cIMT compared to those with the lowest levels. This highlights folate’s potential positive impact on cardiovascular health, particularly in populations with adequate serum folate.
While vitamin B12 showed no significant connection, participants with the highest folate levels experienced a slower increase in cIMT compared to those with the lowest levels. This highlights folate’s potential positive impact on cardiovascular health, particularly in populations with adequate serum folate.
Read More
8
We explored the role of the MTHFR C677T gene polymorphism in patients with coronary heart disease and hypertension using folic acid along with enalapril treatment. Over 540 patients were divided into groups based on folic acid treatment and monitored for a year.
We observed that those receiving folic acid had a lower recurrence of cardiovascular events compared to others. Additionally, the lipid levels showed improvement in the folic acid group. Therefore, folic acid may enhance overall treatment outcomes and patient compliance in managing blood pressure.
We observed that those receiving folic acid had a lower recurrence of cardiovascular events compared to others. Additionally, the lipid levels showed improvement in the folic acid group. Therefore, folic acid may enhance overall treatment outcomes and patient compliance in managing blood pressure.
Read More
8
We explored the relationship between folic acid levels and the outcomes of ischemic stroke in a study involving over 3,500 patients. Our findings indicated that higher folate levels were linked to a 29% reduced risk of death and serious disability after three months.
Conversely, high homocysteine levels correlated with a 52% increased risk of these adverse outcomes. Additionally, we found that part of folate's protective effect was mediated through homocysteine levels. This suggests that folic acid may play a crucial role in improving ischemic stroke prognosis.
Conversely, high homocysteine levels correlated with a 52% increased risk of these adverse outcomes. Additionally, we found that part of folate's protective effect was mediated through homocysteine levels. This suggests that folic acid may play a crucial role in improving ischemic stroke prognosis.
Read More
User Reviews
USERS' SCORE
Good
Based on 21 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved hemoglobin levels
5 people found this helpful
Folic acid aids in treating anaemia. I take it alongside iron supplements to improve my haemoglobin levels. Folic acid enhances iron absorption. It’s often mistakenly viewed as solely for pregnant women, but deficiency can occur in anyone, especially those with gastrointestinal issues. I've raised my haemoglobin to target levels without side effects.
Read More
9
No discomfort experienced
This supplement aids in red blood cell production and maintains cardiovascular health. I have not experienced any discomfort after taking it, and it's affordable; I will buy it again.
Read More
9
Supports overall health
21st Century Folic Acid is excellent for overall health, particularly for women. The easy-to-swallow tablets are made with high-quality ingredients, promoting cardiovascular health and cell production. I highly recommend it for daily intake.
Read More
9
Essential for pregnancy
This supplement is a source of folate and calcium. Folic acid helps maintain cardiovascular and nerve health and is crucial for DNA formation and red blood cell production. It is especially important for pregnant women to help prevent developmental defects.
Read More
7.5
Vitamin boost
90 people found this helpful
Excellent! My wife and I have taken this vitamin for months. I've noticed a boost in my energy levels and can firmly recommend it to anyone seeking a vitamin lift. This vitamin is also beneficial for individuals with chronic health issues, notably cardiovascular disease.
Read More
Frequently Asked Questions
7.5
Vitamin boost
90 people found this helpful
Excellent! My wife and I have taken this vitamin for months. I've noticed a boost in my energy levels and can firmly recommend it to anyone seeking a vitamin lift. This vitamin is also beneficial for individuals with chronic health issues, notably cardiovascular disease.
9
Supports heart health
3 people found this helpful
Folic acid, a crucial B vitamin, supports heart health. Regular intake may reduce stroke risk and cardiovascular disorders, normalising blood pressure and cholesterol levels. It's particularly important during pregnancy for fetal development and preventing early birth.
9
Prevents anaemia
1 people found this helpful
Folic acid is crucial when planning a pregnancy and overall health. Its deficiency can result in anaemia and gastrointestinal issues. It helps control homocysteine, a harmful substance linked to cardiovascular disease and facilitates proper metabolic functions.
9
Improved hemoglobin levels
5 people found this helpful
Folic acid aids in treating anaemia. I take it alongside iron supplements to improve my haemoglobin levels. Folic acid enhances iron absorption. It’s often mistakenly viewed as solely for pregnant women, but deficiency can occur in anyone, especially those with gastrointestinal issues. I've raised my haemoglobin to target levels without side effects.
7.5
Benefits for all
2 people found this helpful
Folic acid benefits everyone, not just pregnant women. It aids nearly all bodily systems, including haemoglobin synthesis and the nervous and cardiovascular systems. It can enhance mood and normalise emotional well-being after childbirth.
7.5
Mood improvement
1 people found this helpful
Folic acid positively impacts the nervous system, which in turn influences my mood and productivity. This vitamin is vital for cellular growth and DNA integrity, preventing the onset of tumours and supporting cardiovascular health. It's beneficial for everyone, not just women.
6
Reduced homocysteine levels
Folic acid works with vitamins B-6 and B-12 to manage elevated homocysteine levels in the blood, which may increase the risk of cardiovascular disease. Research indicates that folate may help reduce the risk of several types of cancer.
7.5
Supports blood health
1 people found this helpful
Folic acid is essential for preventing anaemia and aiding blood formation. It restores immunity and supports cardiovascular health, ensuring proper erythrocyte production when dealing with iron deficiency.
8
Cardiovascular support
3 people found this helpful
After a cardiologist's recommendation, I sought affordable folic acid supplements for heart support. I found 21st Century's option to be cost-effective for long-term use. The tablets are easy to swallow, and the quality is great. My order arrived quickly.
8
We examined the connection between folic acid levels and stroke risk in a study involving nearly 5,000 individuals from a Chinese community. We discovered that participants with higher folate levels had a significantly lower risk of experiencing strokes.
Specifically, those in the highest folate group had a 32% lower risk of stroke compared to those with the lowest levels. We also found that homocysteine levels played a significant role in this relationship. Interestingly, the genetic variation of the MTHFR gene influenced how folate affected stroke risk, revealing a more complex interaction.
Specifically, those in the highest folate group had a 32% lower risk of stroke compared to those with the lowest levels. We also found that homocysteine levels played a significant role in this relationship. Interestingly, the genetic variation of the MTHFR gene influenced how folate affected stroke risk, revealing a more complex interaction.
8
We explored the role of the MTHFR C677T gene polymorphism in patients with coronary heart disease and hypertension using folic acid along with enalapril treatment. Over 540 patients were divided into groups based on folic acid treatment and monitored for a year.
We observed that those receiving folic acid had a lower recurrence of cardiovascular events compared to others. Additionally, the lipid levels showed improvement in the folic acid group. Therefore, folic acid may enhance overall treatment outcomes and patient compliance in managing blood pressure.
We observed that those receiving folic acid had a lower recurrence of cardiovascular events compared to others. Additionally, the lipid levels showed improvement in the folic acid group. Therefore, folic acid may enhance overall treatment outcomes and patient compliance in managing blood pressure.
8
Folate impacts heart health progression
We focused on whether folate and vitamin B12 levels influence the progression of carotid intima-media thickness (cIMT), an early sign of atherosclerosis. Our research covered over 4,200 participants in São Paulo over eight years.
While vitamin B12 showed no significant connection, participants with the highest folate levels experienced a slower increase in cIMT compared to those with the lowest levels. This highlights folate’s potential positive impact on cardiovascular health, particularly in populations with adequate serum folate.
While vitamin B12 showed no significant connection, participants with the highest folate levels experienced a slower increase in cIMT compared to those with the lowest levels. This highlights folate’s potential positive impact on cardiovascular health, particularly in populations with adequate serum folate.
8
We have explored how folate, a vital B-vitamin, may play a crucial role in lowering homocysteine levels, which is linked to heightened risks of cardiovascular diseases. The study highlights how high levels of homocysteine can contribute to atherosclerosis, a silent but dangerous condition leading to heart disease and stroke.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
References
- Liang Z, Fan F, Liu B, Li K, Chen H, et al. Association Between Serum Folate Concentrations and 10-Year Stroke Risk in a Prospective Community Cohort: Mediation and Interaction Analyses. Nutrients. 2024;17. doi:10.3390/nu17010159
- Li L, Ou J, Chen Y, Chen Q, Luo M, et al. Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population. J Health Popul Nutr. 2024;43:220. doi:10.1186/s41043-024-00699-w
- Chen X, Bishai D. Revisiting cost-effectiveness of folic acid supplementation in primary stroke prevention in China: considering vitamin B12 deficiency masking issue. BMC Public Health. 2024;24:3540. doi:10.1186/s12889-024-21005-7
- Palchetti CZ, Gonçalves NG, Suemoto CK, Santos IS, Lotufo PA, et al. Serum folate levels, but not vitamin B12, are associated with slower progression in carotid intima-media thickness in a population exposed to mandatory folic acid fortification. Clin Nutr ESPEN. 2025;65:144. doi:10.1016/j.clnesp.2024.11.034
- Dong J, Li Z, Wang C, Zhang R, Li Y, et al. Dietary folate intake and all-cause mortality and cardiovascular mortality in American adults with non-alcoholic fatty liver disease: Data from NHANES 2003 to 2018. PLoS One. 2024;19:e0314148. doi:10.1371/journal.pone.0314148
- Kaushik A, Bhattacharjee D, Chaudhary V, Dahal S, Devi NK, et al. Hypertension and global DNA methylation: a population-based study in rural, Punjab, India. Sci Rep. 2024;14:25826. doi:10.1038/s41598-024-77437-z
- Ma L, Zeng L, Wang X. MTHFR C677T gene polymorphism in patients with coronary heart disease and hypertension treated with enalapril and folic acid: implications for prognosis. Cell Mol Biol (Noisy-le-grand). 2024;70:142. doi:10.14715/cmb/2024.70.9.20
- Shi M, Zheng J, Liu Y, Mao X, Wu X, et al. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke. J Am Heart Assoc. 2024;13:e036527. doi:10.1161/JAHA.124.036527
- Liang X, Huang D, Bi Y, He Y, Mao T, et al. The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study. J Hum Hypertens. 2024;38:844. doi:10.1038/s41371-024-00955-w
- Prasad K. Atherogenic Effect of Homocysteine, a Biomarker of Inflammation and Its Treatment. Int J Angiol. 2024;33:262. doi:10.1055/s-0044-1788280
